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Art ículos de Investigaci ón 209 Detección precoz de cáncer de pulmón por TC en EPOC - F. Saldías et al 55 y 74 años, fumadores al menos de 30 paq/año o ex-fumadores con menos de 15 años de suspensión del consumo de tabaco15. Aún faltan los estudios de costo-efectividad y de seguimiento a largo plazo que permitan avalar esta recomendación. Referencias 1. World Health Organization. International Agency for Research on Cancer. GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012. Lung Cancer. Accessed June 20, 2015. 2. Centers for Disease Control and Prevention. National Center for Health Statistics. CDC WONDER On-line Database, compiled from Compressed Mortality File 1999-2012 Series 20 No. 2R, 2014. 3. American Cancer Society. Cancer Facts & Figure 2013. Atlanta, GA: American Cancer Soc; 2013. 4. Ministerio de Salud. Gobierno de Chile. Departamento de Estadísticas e Información de Salud. Serie de mortalidad por causa 2000-2012. http://deis.minsal.cl/vitales/ Mortalidad_causa/Chile.htm 5. Strauss GM. Screening for lung cancer: an evidence-based synthesis. Surg Oncol Clin N Am 1999; 8: 747-74. 6. Osann KE. Lung cancer in women: the importance of smoking, family history of cancer, and medical history of respiratory disease. Cancer Res 1991; 51: 4893-7. 7. Burns DM. Primary prevention, smoking, and smoking cessation: implications for future trends in lung cancer prevention. Cancer 2000; 89 (11 Suppl): 2506-9. 8. Halpern MT, Gillespie BW, Warner KE. Patterns of absolute risk of lung cancer mortality in former smokers. J Natl Cancer Inst 1993; 85: 457-64. 9. Raji OY, Duffy SW, Agbaje OF, Baker SG, Christiani DC, Cassidy A, et al. Predictive accuracy of the Liverpool Lung Project risk model for stratifying patients for computed tomography screening for lung cancer: a case-control and cohort validation study. Ann Intern Med 2012; 157: 242-50. 10. Tammemagi MC, Katki HA, Hocking WG, Church TR, Caporaso N, Kvale PA, et al. Selection criteria for lung-cancer screening. N Engl J Med 2013; 368: 728-36. 11. Kovalchik SA, Tammemagi M, Berg CD, Caporaso NE, Riley TL, Korch M, et al. Targeting of low-dose CT screening according to the risk of lung-cancer death. N Engl J Med 2013; 369: 245-54. 12. Ministerio de Salud. Exposición a tabaco. Encuesta Nacional de Salud 2009-2010, Chile. Páginas 152-88. 13. Doria-Rose VP, Szabo E. Screening and prevention of lung cancer. In: Kern-stine, KH; Reckamp, KL, editors. Lung cancer: a multidisciplinary approach to diagnosis and management. New York: Demos Medical Publishing; 2010, page 53-72. 14. Naidich DP, Marshall CH, Gribbin C, Arams RS, McCauley DI. Low-dose CT of the lungs: preliminary observations. Radiology 1990; 175: 729-31. 15. Bach PB, Mirkin JN, Oliver TK, Azzoli CG, Berry DA, Brawley OW, et al. Benefits and harms of CT screening for lung cancer: a systematic review. JAMA 2012; 307: 2418-29. 16. National Lung Screening Trial Research Team, Aberle DR, Adams AM, Berg CD, Black WC, Clapp JD, Fagerstrom RM, et al. Reduced lung-cancer mortality with low-dose computed tomographic screening. N Engl J Med 2011; 365: 395-409. 17. Díaz AA, Morales A, Díaz JC, Ramos C, Klaassen J, Saldías F, et al. CT and physiologic determinants of dyspnea and exercise capacity during the six-minute walk test in mild COPD. Respir Med 2013; 107: 570-9. 18. Global Initiative for Chronic Obstructive Lung Disease (GOLD). Global strategy for the diagnosis, management and prevention of chronic obstructive pulmonary disease 2015. www.goldcopd.com 19. Mahler DA, Wells CK. Evaluation of clinical methods for rating dyspnea. Chest 1988; 93: 580-6. 20. Burge S, Wedzicha JA. COPD exacerbations: definitions and classifications. Eur Respir J 2003; 41 (Suppl): 46S-53S. 21. Henschke CI, Yankelevitz DF, Libby DM, McCauley D, Pasmantier M, Altorki NK, et al. Early lung cancer action project: annual screening using single-slice helical CT. Ann N Y Acad Sci 2001; 952: 124-34. 22. Miller MR, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, et al. Standardisation of spirometry. Eur Respir J 2005; 26: 319-38. 23. Hankinson JL, Odencrantz JR, Fedan KB. Spirometric reference values from a sample of the general U.S. population. Am J Respir Crit Care Med 1999; 159: 179-87. 24. American Thoracic Society Statement. Guidelines for the six-minute walk test. Am J Respir Crit Care Med 2002; 166: 111-7. 25. Troosters T, Gosselink S, Decramer M. Six minute walking distance in healthy elderly subjects. Eur Respir J 1999; 14: 270-4. 26. Borg GA. Psychophysical basis of perceived exertion. Med Sci Sports Exerc 1982; 14: 377-81. 27. Celli BR, Cote CG, Marín JM, Casanova C, Montes de Oca M, Méndez RA, et al. The body-mass index, airflow obstruction, dyspnea and exercise capacity index in chronic obstructive pulmonary disease. N Engl J Med 2004; 350: 1005-12. Rev Med Chile 2016; 144: 202-210


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