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Revista Medica de Chile Enero 2016

ARTÍCULOS DE INVESTIGACIÓN 71 Linfonodo centinela isotópico en cáncer de mama - P. Humeres et al imágenes prequirúrgicas, ya que en la mayoría de los casos el drenaje será a la axila correspondiente46. En nuestro estudio, de rutina se adquieren imágenes en todos los pacientes. En nuestra revisión hemos podido comprobar la alta detección de LC con técnica isotópica, tanto antes de la cirugía, como en pabellón al ser realizada por cirujanos y médicos nucleares entrenados. Nuestros resultados de compromiso axilar y subsecuentemente de DLA, también son similares a lo publicado en la literatura. El uso de la técnica de LC evitó DLA innecesarias en aproximadamente dos tercios de pacientes con LC negativo. En nuestra experiencia la técnica de LC es un método útil y sencillo de realizar en la estadificación axilar de los cánceres de mama en etapas precoces. Referencias 1. Morton DL, Wen DR, Wong JH, Economou JS, Cagle LA, Storm FK et al. Technical details of  intraoperative lymphatic mapping for early stage melanoma. Arch Surg 1992; 127 (4): 392-9. 2. Cabañas RM. An approach for the treatment of penile carcinoma. Cancer 1977; 39 (2): 456-66. 3. Krag DN, Weaver DL, Alex JC, Fairbank JT. Surgical resection and radiolocalization of the sentinel lymph node in breast cancer using a gamma probe.  Surg Oncol 1993; 2 (6): 335-9. 4. Krag DN, Anderson SJ, Julian TB, Brown AM, , Ashikaga T, et al. Technical outcomes of sentinel-lymph-node resection and conventional axillary-lymph-node dissection in patients with clinically node-negative breast cancer: results from the NSABP B-32 randomised phase III trial. Lancet Oncol 2007; 8 (10): 881-8. 5. Albertini JJ, Lyman GH, Cox C, Yeatman T, Balducci L, Ku N, et al. Lymphatic mapping and sentinel node biopsy in the patient with breast cancer. JAMA 1996; 276 (22): 1818-22. 6. Cody HS 3rd, Fey J, Akhurst T, Fazzari M, Mazumdar M, Yeung H, et al. Complementarity of blue dye and isotope in sentinel node localization for breast cancer: univariate and multivariate analysis of 966 procedures. Ann Surg Oncol 2001; 8 (1): 13-9. 7. Lucci A, McCall LM, Beitsch PD, Whitworth PW, Reintgen DS, Blumencranz PW, et al. Surgical complications associated with sentinel lymph node dissection (SLND) plus axillary lymph node dissection compared with SLND alone in the American College of Surgeons Oncology Group Trial Z0011. J Clin Oncol 2007; 25 (24): 3657-63. 8. Mansel RE, Fallowfield L, Kissin M, Goyal A, Newcombe RG, Dixon JM, et al. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. J Natl Cancer Inst 2006; 98 (9): 599-609. 9. Fleissig A, Fallowfield LJ, Langridge CI, Johnson L, Newcombe RG, Dixon JM, et al. Post-operative arm morbidity and quality of life. Results of the ALMANAC randomised trial comparing sentinel node biopsy with standard axillary treatment in the management of patients with early breast cancer. Breast Cancer Res Treat. 2006; 95 (3): 279-93. 10. Latosinsky S, Dabbs K, Moffat F; Evidence-Based Reviews in Surgery Group. Canadian Association of General Surgeons and American College of Surgeons Evidence-Based Reviews in Surgery. 27. Quality-of-life outcomes with sentinel node biopsy versus standard axillary treatment in patients with operable breast cancer. Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. Can J Surg 2008; 51 (6): 483-5. 11. Gill G, SNAC Trial Group of the Royal Australasian College of Surgeons (RACS) and NHMRC Clinical Trials Centre. Sentinel-lymph-node-based management or routine axillary clearance? One-year outcomes of sentinel node biopsy versus axillary clearance (SNAC): a randomized controlled surgical trial. Ann Surg Oncol 2009; 16 (2): 266-75. 12. Ashikaga T, Krag DN, Land SR, Julian TB, Anderson SJ, Brown AM, et al. Morbidity results from the NSABP B-32 trial comparing sentinel lymph node dissection versus axillary dissection. J Surg Oncol 2010; 102 (2): 111-8. 13. Land SR, Kopec JA, Julian TB, Brown AM, Anderson SJ, Krag DN, et al. Patient-reported outcomes in sentinel node-negative adjuvant breast cancer patients receiving sentinel-node biopsy or axillary dissection: National Surgical Adjuvant Breast and Bowel Project phase III protocol B-32. J Clin Oncol 2010; 28 (25): 3929-36. 14. Mabry H, Giuliano AE. Sentinel node mapping for breast cancer: progress to date and prospects for the future. Surg Oncol Clin N Am 2007; 16 (1): 55-70. 15. Lyman GH, Giuliano AE, Somerfield MR, Benson AB 3rd, Bodurka DC, Burstein HJ, et al. American Society of Clinical Oncology guideline recommendations for sentinel lymph node biopsy in early-stage breast cancer. J Clin Oncol 2005; 23 (30): 7703-20. 16. Krag D, Weaver D, Ashikaga T, Moffat F, Klimberg Rev Med Chile 2016; 144: 66-73


Revista Medica de Chile Enero 2016
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