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Mayo 2016

Table 1. Age, sex and plasma 25(OH)D status of the hasimoto’s thyroiditis and control groups p Age (years) 12.15 ± 4.06 10.09 ± 4.44 < 0.05 Sex n (%) Female 0.47 Male 25OHD (ng/mL) 16.8 ± 9.2 24.1 ± 9.4 < 0.001 613 artículos de investigación groups, one-way ANOVA test forcomparison of more than two groups and a Pearson correlation test for determination of associations between variables. P < 0.05 was considered to indicate statistical significance. Results This study consisted of 68 patients diagnosed with HT in Gaziosmanpasa University Pediatrics Clinic between 2010 and 2014 and 68 healthy, age and gender-matched children. The mean age in the patient group was 12.15 ± 4.06 years (39 females, 29 males) and 10.09 ± 4.44 years in the control group (37 females, 31 males; P < 0.05 (Table 1). The mean 25OHD level in the patient group was significantly lower than in the control group (16.85 ± 9.26 vs 24.13 ± 9.4 ng/mL; P < 0.001 (Figure 1). The frequency of vitamin D deficiency was 76% in the HT group and 35% in the control group (P < 0.001 (Table 2). Among the patients with HT, 5 (7.4%) had PHT, 32 (47.1%) SCHT and 31 (45.6%) ET. All HT patients who had PHT were vitamin D-deficient. The mean vitamin D levels were 14.7 ng/mL in patients with PHT (n = 5), 18.8 ng/mL in patients with SCHT (n = 32) and 15.1 ng/mL in patients with ET (n = 31). Although patients with PHT had low vitamin D levels, there was no statistical difference between PHT, SCHT and ET. Anti-TPO and vitamin D levels were negatively correlated in patients with HT although without statistical significance (r = -0.22, P = 0.065). Vitamin D and PTH levels were correlatedin patients with HT (r = -0.32, P = 0.006). There was no statistically significant correlation between vitamin D and TSH levels (r = -0.105, P = 0.3). Vitamin D levels were not significantly associated with calcium, phosphorus, ALP or PTH levels. Discussion HT is the most common endocrine disease in children16. Although autoimmunity is important in HT pathogenesis, genetic and environmental factors playa role. The disease, in which cellular and humoral immune responses occur at varying degrees, is characterized by a progressive destruction of the thyroid tissue. Pathologically, thyroid Case (n = 68) Control (n = 68) 39 (57) 29 (42) 37 (54) 31 (45) Figure 1. Vitamin D levels in hasimoto’s thyroiditis and control groups (P < 0.001). Table 2. Frequency distribution of categorical vitamin D in study subject Case (n = 68) Control (n = 68) Total Vitamin D deficiency 52 (76) 24 (35) 76 (56) Vitamin D insufficiency 9 (13) 30 (44) 39 (29) Normal 7 (10) 14 (20) 21 (15) tissue is distinguishedby profound T lymphocyte infiltration3,17,18. Apart from the effect of active vitamin D on calcium, phosphorus and bone metabolism, vitamin D has immune regulatory and anti-inflammatory functions19. Vitamin D exerts its biological effects via vitamin D receptor (VDR) on the target cells8,20. VDR has been identified in all immune system cells. Furthermore, the Hypovitaminosis D in Children - E. Sönmezgöz et al Rev Med Chile 2016; 144: 611-616


Mayo 2016
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