Hypovitaminosis D in Children with Hashimoto’s Thyroiditis

Mayo 2016

611 artículos de investigación Hashimoto’s thyroiditis (HT) is a chronic autoimmune disease of the thyroid gland and is the most common cause of acquired hypothyroidism that presents in children and adults with or without goiter in areas where iodine deficiency is not endemic1. Worldwide annual incidence of HT is approximately 0.3-1.5/1,0002. Autoimmunity as well as environmental and genetic susceptibilities are important in pathogenesis. The disease is characterized by the reactivity to Rev Med Chile 2016; 144: 611-616 Hypovitaminosis D in Children with Hashimoto’s Thyroiditis ERGÜN SÖNMEZGÖZ1,a, SAMET OZER1,a, RESUL YILMAZ1,a, YALÇIN ÖNDER2,a, ILKNUR BÜTÜN3,a, SERAP BILGE1,b ABSTRACT Background: Vitamin D deficiency or insufficiency may play a role in the pathogenesis of certain autoimmune diseases. Aim: To measure vitamin D levels in children with Hashimoto’s thyroiditis (HT) (either with subclinical or marked hypothyroidism) and in healthy controls. Material and Methods: We included 68 children with HT aged 12 ± 4 years (39 females) from a pediatric outpatient clinic and 68 healthy children aged 10 ± 4 years (37 females). Calcium metabolism parameters, thyroid function tests and anti-thyroid peroxidase (anti-TPO), anti-thyroglobulin (anti-TG) and 25 hydroxy vitamin D (25OHD) levels were measured. Results: Patients were older than controls but well matched by gender distribution. Mean 25OHD levels were significantly lower in HT patients than controls (16.8 ± 9.3 and 24.1 ± 9.4 ng/mL respectively, P < 0.01). Frequency of vitamin D deficiency was 76 and 35% in HT patients and controls, respectively (P < 0.001). Conclusions: Vitamin D deficiency is more common in children with HT than healthy controls. (Rev Med Chile 2016; 144: 611-616) Key words: Hashimoto Disease; Hypothyroidism; Vitamin D Deficiency. Hipovitaminosis D en niños con tiroiditis de Hashimoto Antecedentes: La deficiencia o insuficiencia de vitamina D puede tener un rol en la patogenia de enfermedades autoinmunes. Objetivo: Medir niveles de vitamina D en niños con tiroiditis de Hashimoto (TH) (con hipotiroidismo subclínico o marcado) y en controles sanos. Material y Métodos: Estudiamos 68 niños con TH, de 12 ± 4 años (39 mujeres) y 68 controles sanos de 10 ± 4 años (37 mujeres). Se les midió parámetros de metabolismo de calcio, pruebas de función tiroidea, anticuerpos anti peroxidasa y anti tiroglobulina y 25 hidroxi vitamina D (25 OH vit D). Resultados: Los pacientes eran mayores que los controles pero la distribución por género era homogénea en ambos grupos. Los niveles de 25 OH vit D en pacientes y controles fueron 16,8 ± 9,3 y 24,1 ± 9,4 ng/mL respectivamente, p < 0,01. La frecuencia de deficiencia de vitamina D fue de 76 y 35% en pacientes y controles, respectivamente. Conclusiones: La deficiencia de vitamina D es más común en niños con TH. 1Department of Pediatrics, School of Medicine Gaziosmanpasa University Tokat-Turkey. 2Department of Public health, School of Medicine Gaziosmanpasa University Tokat- Turkey. 3Department of Biochemistry, School of Medicine Gaziosmanpasa University Tokat- Turkey. aM.D. Assistant Professor. bM.D. Conflicting Interest: The authors declare that they have no conflict of interest. Source(s) of support: Presentation at a meeting: N/A. Recibido el 30 de octubre de 2015, aceptado el 9 de marzo de 2016. Corresponding Author: Ergün Sönmezgöz Gaziosmanpaşa Üniversitesi Tip Fakültesi Pediatri AD 60150 Tokat/Turkey. Phone: 0090 356 2121001 GSM: 0090 533 9318080 Facsimile: 0090 356 2122142 esonmezgoz@gmail.com


Mayo 2016
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