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casos cl ínicos Sirolimus en Enfermedad de Erdheim-Chester - J. Vega et al F, Doglioni C, et al. Tumor necrosis factor α as a master regulator of inflammation in Erdheim-Chester disease: rationale for the treatment od patients with infliximab. J Clin Oncol 2012; 30: e286-e290. 18. Haroche J, Charlotte F, Arnaud L, von Deimling A, Hélias-Rodzewicz Z, Hervier B, et al. High prevalence of BRAF V600E mutations in Erdheim-Chester disease but not in other non-Langerhans cell histiocytoses. Blood 2012; 120: 2700-3. 19. Graziani G, Podestá MA, Cucchiari D, Reggiani F, Ponticelli 400 C. Erdheim-Chester disease: from palliative care to targeted treatment. Clin Kidney J 2014; 7: 339-43. 20. Myra C, Sloper L, Tighe P, McIntosh RS, Stevens SE, Gregson RH, et al. Treatment of Erdheim-Chester disease with cladribine: a rational approach. Br J Ophthalmol 2004; 88: 844-7. 21. Gianfreda D, Nicastro M, Galetti M, Alberici F, Corradi D, Becchi G, et al. Sirolimus plus prednisone for Erdheim Chester disease: an open-label trial. Blood 2015; 126: 1163-71. 22. Vega J, Cisternas M, Bergoeing M, Espinosa R, Zapico A, Chadid P, et al. Enfermedad de Erdheim-Chester. Una causa rara de derrame pericárdico. Caso clínico. Rev Med Chile 2011; 139: 1054-9. 23. Vaglio A, Casazza I, Alberici F, Palmisano A, Foti R, Moroni G, et al. Sirolimus plus prednisone for the treatment of Erdheim-Chester disease. A pilot study. Presentado en World Congress of Nephrology, Milan, mayo 22-26, 2009. 24. Arnaud L, Gorochov G, Charlotte F, Lvovschi V, Parizot C, Larsen M, et al. Systemic perturbation of cytokine and chemokine networks in Erdheim-Chester disease: a single-center series of 37 patients. Blood 2011; 117: 2783-90. 25. Long-term Outcome After Vemurafenib/BRAF Inhibitors Interruption in Erdheim-chester Disease (LOVE). Accedido el 29 de septiembre de 2015 en: https://www. clinicaltrials.gov/ct2/show/NCT02089724?term=Erdheim Chester&rank=2. 26. Dabrafenib and Trametinib in People With BRAF V600E Mutation Positive Lesions in Erdheim Chester Disease. Accedido el 29 de septiembre de 2015 en: https:// www.clinicaltrials.gov/ct2/show/NCT02281760?- term=Erdheim-Chester&rank=4. 27. Pilot Study of Tocilizumab in Patients With Erdheim Chester Disease. Accedido el 29 de septiembre de 2015 en: https://www.clinicaltrials.gov/ct2/show/ NCT01727206?term=Erdheim-Chester&rank=1. Rev Med Chile 2016; 144: 394-400


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