ARTÍCULOS DE INVESTIGACIÓN - Evaluación del valor pronóstico de larelación neutrófilos/linfocitos en cáncerde mama de subtipos agresivos

Junio 2016

ARTÍCULOS DE INVESTIGACIÓN 691 Rev Med Chile 2016; 144: 691-696 Evaluación del valor pronóstico de la relación neutrófilos/linfocitos en cáncer de mama de subtipos agresivos Ximena Mimica1, Francisco Acevedo2, David Oddo3, Carolina Ibáñez2, Lidia Medina2, Alexis Kalergis4, Mauricio Camus1, César Sánchez2 Neutrophil/lymphocyte ratio in complete blood count as a mortality predictor in breast cancer Background: The white blood cell count is one of the most sensitive markers associated with inflammation. The neutrophil/lymphocyte count ratio may be an independent factor for breast cancer mortality. Aim: To assess the predictive value of the neutrophil/lymphocyte ratio for mortality in breast cancer. Material and Methods: Review of the database of a cancer center of a University hospital. Patients with infiltrating breast cancer treated between 1997 and 2012 were selected. The pathology type and lymph node involvement were obtained from the pathology report. The expression of estrogen, progesterone and Human Epidermal Growth Factor Receptor 2 (HER2) was determined by immunohistochemistry or in situ fluorescent hybridization (FISH). The absolute peripheral neutrophil and lymphocyte counts were obtained from a complete blood count obtained at least three months before treatment. Patients were followed for a median of 61 months (range 1-171). Results: From 323 eligible patients, after excluding those in stage IV and those without an available complete blood count, 131 patients were analyzed (81 with negative receptors and 117 HER2 enriched). The neutrophil/lymphocyte ratio was similar in both types of tumors (2.1 and 1.91 respectively). Twenty two patients died during follow-up. Surviving patients with HER2 enriched tumors had a lower neutrophil/lymphocyte ratio than those who died (1.79 and 3.21 respectively, p < 0.01). In a multivariate analysis, including age, tumor stage and lymph node involvement as confounding factors, the neutrophil/lymphocyte ratio was still significantly associated with a risk of death with a hazard ratio of 2.56. Conclusions: A high neutrophil/lymphocyte ratio in the complete blood count can be a predictor of death in breast cancer. (Rev Med Chile 2016; 144: 691-696) Key words: Breast Neoplasms; Inflammation; Prognosis. 1Departamento de Cirugía Oncológica. Facultad de Medicina. Pontificia Universidad de Chile. Santiago, Chile. 2Departamento de Hematología- Oncología. Facultad de Medicina. Pontificia Universidad de Chile. Santiago, Chile. 3Departamento de Anatomía Patológica. Facultad de Medicina. Pontificia Universidad de Chile. Santiago, Chile. 4Facultad de Ciencias Biológicas. Facultad de Medicina. Pontificia Universidad de Chile. Santiago, Chile. Recibido el 4 de octubre de 2015, aceptado el 6 de abril de 2016. Correspondencia a: Dr. César Sánchez csanchez@med.puc.cl El cáncer de mama (CM) es la neoplasia más común en mujeres1 y la principal causa de muerte por cáncer en chilenas2. Mientras la mayoría de las neoplasias de mama son estrógeno dependientes, hasta 25% no expresan el receptor de estrógenos (RE) y/o progesterona (RP)3. Estas últimas pueden sobreexpresar HER2 o no expresar ninguno de estos tres receptores (RE, RP y HER2), habitualmente estudiados en muestras de CM. Tumores que no expresan receptores hormonales (RE- y RP-) y sin expresión de HER2 se denominan TN. Por otra parte, aquellos


Junio 2016
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