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Abril 2016

ARTÍCULOS DE INVESTIGACIÓN The effect of benzodiazepines on bronchoconstriction in asthma patients - M. Miric et al Figure 2. The effect of methacholine on values of forced expiratory volume in first second (FEV1) of patients with asthma, before and after inhalation of diazepam. Panel A: The first day of testing, inhalation of methacholine caused a dose dependent response and the reduction of FEV1. On the second day of study, previously given diazepam lowered the changes of FEV1 curve. Panel B: Shows movement of FEV1 and response to methacholine in relation to time (30 minutes), prior to (1.69 L) and after (2.21 L) inhalation of benzodiazepines. 438 Panel A Panel B Figure 3 and 4 present summarized data of the relationship between VC and FEV, where patients were treated only with methacholine and methacholine with previous administration of diazepam. VC is given as a function of changes in the static parameters of lung function, FEV1 indicates a change of the dynamic parameters of lung function . Figure 3 shows the effect of diazepam on changes of VC caused by inhalation of methacholine in patients with asthma. On the first day of study, administering methacholine reduced VC of patients (from 3.8 L to 3.1 L) (p < 0.05, n =  12). On the second day of testing, changes in VC after inhalation of methacholine were not significant if diazepam had been previously inhaled in a concentration of 1.7•10-2M, for a period of 5 minutes (p > 0.5). Values are given as mean values of X ± SE . The graph 4 shows the cumulative change in Figure 3. The effect of benzodiazepines on the changes of VC induced by methacholine in patients with asthma. On the first day of study, methacholine given by inhalation resulted in the decrease in VC of tested patients. In the second day of testing, a changes in VC after inhaled methacholine were not significant, if previously benzodiazepines (diazepam) were inhaled. Values are given as mean values of X ± SE. Rev Med Chile 2016; 144: 434-441


Abril 2016
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