Page 107

Abril 2016

LABORATORIO CLÍNICO 513 The association between miRNA SNPs and HCC - W. Li et al Indexes Genotype P value Allele P value AFP miR-449b rs10061133 AA GG AG 0.628 A G 0.644 < 20 μg/L 102 14 64 268 92 ≥ 20 μg/L 174 17 113 461 147 miR-3152 rs13299349 AA GG AG 0.933 A G 0.911 < 20 μg/L 1 147 34 36 328 ≥ 20 μg/L 1 246 56 58 548 Total bilirubin (μmol/L) miR-449b rs10061133 AA 21.01 ± 39.28 GG 17.32 ± 12.40 AG 15.91 ± 7.68 0.413 A 19.72 ± 34.22 G 16.28 ± 9.10 0.481 miR-3152 rs13299349 AA 18.50 ± 0.85 GG 19.09 ± 32.67 AG 17.69 ± 12.17 0.435 A 17.72 ± 11.90 G 18.95 ± 31.20 0.534 Direct bilirubin (μmol/L) miR-449b rs10061133 AA 10.64 ± 30.46 GG 7.06 ± 5.68 AG 6.79 ± 4.00 0.116 A 9.68 ± 26.47 G 6.86 ± 4.47 0.553 miR-3152 rs13299349 AA 7.30 ± 0.14 GG 9.13 ± 25.18 AG 8.20 ± 8.65 0.389 A 8.16 ± 8.46 G 9.04 ± 24.02 0.719 Indirect bilirubin (μmol/L) miR-449b rs10061133 AA 10.47 ± 9.54 GG 10.28 ± 7.04 AG 9.10 ± 4.27 0.740 A 10.12 ± 8.54 G 9.40 ± 5.14 0.574 miR-3152 rs13299349 AA 11.50 ± 0.71 GG 10.04 ± 8.38 AG 9.41 ± 4.62 0.099 A 9.50 ± 4.54 G 9.98 ± 8.08 0.238 ALT (U/L) miR-449b rs10061133 AA 62.38 ± 100.40 GG 48.82 ± 29.74 AG 57.16 ± 75.00 0.825 A 61.08 ± 94.60 G 54.95 ± 66.10 0.373 miR-3152 rs13299349 AA 24.95 ± 5.02 GG 57.97 ± 79.93 AG 6.93 ± 118.84 0.713 A 65.16 ± 116.60 G 58.88 ± 84.65 0.963 AST (U/L) miR-449b rs10061133 AA 66.01 ± 98.59 GG 60.28 ± 48.05 AG 61.22 ± 79.28 0.354 A 64.81 ± 94.03 G 60.97 ± 72.14 0.326 miR-3152 rs13299349 AA 42.35 ± 29.77 GG 61.70 ± 75.08 AG 73.19 ± 134.22 0.267 A 71.89 ± 131.55 G 62.88 ± 83.06 0.780 HBV-DNA (IU/mL) miR-449b rs10061133 AA 1583964.34 ± 4540391.941 GG 1515975.00 ± 3038757.99 AG 1609109.30 ± 4362730.17 0.524 A 1590250.58 ± 448347.55 G 1583852.54 ± 4024565.63 0.303 miR-3152 rs13299349 AA 0 GG 1637911.34 ± 4401178.60 AG 1405658.33 ± 4310651.52 0.889 A 1405658.33 ± 4310651.52 G 1618191.75 ± 4383803.50 0.957 CEA (μg/L) miR-449b rs10061133 AA 7.55 ± 42.46 GG 2.41 ± 1.55 AG 2.69 ± 1.95 0.554 A 6.34 ± 36.84 G 2.61 ± 1.86 0.606 miR-3152 rs13299349 AA 3.15 ± 2.05 GG 6.03 ± 35.35 AG 2.64 ± 1.87 0.925 A 2.67 ± 1.86 G 5.69 ± 33.52 0.969 CA199 (U/ml) miR-449b rs10061133 AA 43.43 ± 69.33 GG 45.32 ± 60.81 AG 41.72 ± 89.42 0.834 A 43.01 ± 74.66 G 42.70 ± 82.41 0.158 0.970 miR-3152 rs13299349 AA 34.55 ± 33.59 GG 45.25 ± 81.64 AG 33.28 ± 47.62 0.996 A 33.34 ± 46.75 G 44.08 ± 78.98 *P value less than 0.05. Rev Med Chile 2016; 144: 508-515


Abril 2016
To see the actual publication please follow the link above