Page 106

Abril 2016

LABORATORIO CLÍNICO 512 The association between miRNA SNPs and HCC - W. Li et al Table 3. Association between genotypes/alleles of miR-3152 rs13299349 and miR-449b rs10061133 and the risk of HCC Genotype Control HCC patients HCC patients with HBV Number (%) Number (%) OR (95% CI)a Pa Number (%) OR (95% CI)a Pa rs13299349 n = 520 n = 495 n = 394 GG 398 (76.5) 402 (81.2) 1 320 (81.2) 1 0 AA 9 (1.7) 2 (0.4) 1.260 (0.908-1.750) 0.167 1 (0.3) 1.230 (0.860-1.761) 0.257 GA 113 (21.7) 91 (18.4) 0.227 (0.045-1.159) 0.075 73 (18.5) 0.122 (0.014-1.088) 0.060 Dominant model 1.344(0.974-1.855) 0.072 1.331(0.936-1.894) 0.112 (AA+AG vs GG) Recessive model (AA vs AG+GG) 5.286(1.059-26.379) 0.042* 9.657(1.105-84.395) 0.040* G 729 (70.6) 739 (74.8) 1 581 (73.7) 1 A 303 (29.4) 249 (25.2) 1.386 (1.031-1.864) 0.031* 207 (26.3) 1.396 (1.008-1.934) 0.045* rs1006113 n = 516 n = 494 n = 394 AA 257 (49.8) 278 (56.3) 1 215 (54.6) 1 GG 44 (8.5) 33 (6.7) 1.231 (0.934-1.621) 0.140 28 (7.1) 1.119 (0.830-1.510) 0.460 AG 215 (41.7) 183 (37.0) 0.806 (0.478-1.360) 0.419 151 (38.3) 0.773 (0.440-1.357) 0.370 Dominant model 1.274 (0.980-1.657) 0.071 1.167(0.878-1.553) 0.288 (AA vs AG+GG) Recessive model (AA+AG vs GG) 1.398 (0.849-2.301) 0.188 1.379 (0.806-2.360) 0.241 A 729 (70.6) 739 (74.8) 1 581 (73.7) 1 G 303 (29.4) 249 (25.2) 1.234 (1.002-1.520) 0.048* 207 (26.3) 1.166 (0.931-1.460) 0.182 aORs and p values were all obtained after adjusting for age, gender and smoking status. *p value less than 0.05. Table 4. Association between the genotypic/allelic frequencies of miRNA SNPs and clinical indexes in HCC patients Indexes Genotype P value Allele P value Size of tumor foci miR-449b rs10061133 AA GG AG 0.367 A G 0.764 < 5 cm 70 10 35 175 55 ≥ 5 cm 89 10 61 239 81 miR-3152 rs13299349 AA GG AG 0.072 A G 0.036* < 5 cm 0 100 17 17 217 ≥ 5 cm 1 120 40 42 280 Number of tumor foci miR-449b rs10061133 AA GG AG 0.224 A G 0.522 Single 139 17 90 368 124 Multiple 20 3 6 46 12 miR-3152 rs13299349 AA GG AG 0.003* A G 0.378 Single 0 193 55 55 441 Multiple 1 27 2 4 56 Rev Med Chile 2016; 144: 508-515


Abril 2016
To see the actual publication please follow the link above